| 1. | Within the brain, quinolinic acid is only produced by activated microglia and macrophages.
|
| 2. | When inflammation occurs, quinolinic acid is produced in excessive levels through the kynurenine pathway.
|
| 3. | Quinolinic acid has also been found in HAND patients brains.
|
| 4. | Microglia and macrophages produce the vast majority of quinolinic acid present in the body.
|
| 5. | In this way, quinolinic acid self-potentiates its own toxicity.
|
| 6. | A third abused child in the sample did not have elevated levels of quinolinic acid.
|
| 7. | Quinolinic acid is also the bioprecursor of NAD +.
|
| 8. | Researchers utilize quinolinic acid in order to study Huntington s disease in many model organisms.
|
| 9. | Similar to HIV patients, this increased quinolinic acid concentration correlates with cognitive and motor dysfunction.
|
| 10. | Quinolinic acid's neuroactive and excitatory properties are a result of NMDA receptor agonism in the brain.
|
मोबाइल